The integration of artificial intelligence (AI) in clinical trials promises to revolutionize patient engagement, data management, and overall trial efficiency. However, these advancements come with significant ethical considerations. This presentation delves into the use of AI avatars in patient interactions and how patients perceive this new dynamic. It examines the disparity in health and technology literacy among patients and questions whether we are adequately supporting those less familiar with these tools. The talk also explores the democratization of health data, empowering patients to make informed choices, and the associated risks of data privacy and security, particularly regarding injection attacks. By addressing these topics, we aim to balance innovation with ethical responsibility, ensuring that AI enhances clinical trials without compromising patient trust and safety.