[Panel webinar] A dissection of SARS-CoV-2 with primary human lung culture systems
How to model the pathobiology and therapeutic treatments for Covid-19 using human lung organoids
Join Pharma IQ and The Sartorius Group for an overview of the methods for human lung organoids and quantitative assessment of biological effects of the SARS-CoV-2 infection
In this session, supported by The Sartorius Group, hosts Sandra Lawrynowicz Leibel, Assistant Professor of Pediatrics, and Ben Broker, Associate Professor, both at the University of California, San Diego (UCSD), will explore the latest cell culture methods for the current generation of human lung culture systems, as well as revealing what is required for a quantitative assessment of infection by SARS-CoV-2.
The industry experts will take a deep dive into an investigation of SARS-CoV-2 using human lung cell models, including air liquid interphase cultures of bronchial epithelial cells and human pluripotent stem cell.
They will also explore derived lung organoids containing epithelial cells of the distal parenchyma (alveolar type 1 and 2 cells), upper airway (basal, ciliated and secretory cells), and stromal cells important in studying inflammatory epithelial-mesenchymal transitioning.
Join this session to discover:
- The latest cell culture methods for generation of human lung culture systems.
- What is required for a quantitative assessment of infection by SARS-CoV-2.
- How to carry out therapeutic testing for COVID-19 using human lung cells.
- A dissection of SARS-CoV-2 variants using a permissive primary human cell type.
- Why to use live cell imaging to investigate pathobiology of SARS-CoV-2 infection.
Presenters:
Sandra Lawrynowicz Leibel, Assistant Professor of Pediatrics at UCSD
Sandra Lawrynowicz Leibel is a neonatologist and lung biology researcher, who initially joined UCSD as a physician scientist. Her current focus is on studying early lung development, surfactant metabolism and pulmonary infectious disease at the bench and bedside.
In the lab, she studies the impact of surfactant deficiency on lung development using a novel stem cell derived 3D multi-cellular lung organoid model system or ‘mini-lung’ in a dish, allowing her to study mechanisms of development and disease and potential therapeutics.
Ben Croker, Associate Professor, Department of Pediatrics at UCSD
Ben Croker is an immunologist in the Division of Rheumatology, Allergy and Immunology. His current focus is the role of apoptotic and inflammatory cell death in autoinflammatory and infectious disease. His lab uses live cell imaging and novel image analysis tools to investigate neutrophilic inflammatory diseases and SARS-CoV-2-induced cell death and viral dissemination.
